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AstraZeneca has garnered significant attention in recent years, particularly for developing one of the COVID vaccines that are making a difference globally. Recently, on September 19, the company captured headlines again at the 2021 European Society of Medical Oncology with remarkable findings regarding a new breast cancer medication.
In clinical trials, Enhertu demonstrated an extraordinary 72 percent reduction in the risk of death or disease progression for patients diagnosed with HER-2-positive metastatic breast cancer when compared to the existing treatment protocols. Susan Harrington, the senior vice president of Oncology R&D at AstraZeneca, emphasized the drug’s life-saving potential, stating, “These unparalleled results could signify a transformative shift in managing HER-2-positive metastatic breast cancer and highlight Enhertu’s capability to change the lives of many patients earlier in their treatment journey.”
A Transformative Solution for a Challenging Disease
Breast cancer remains the most frequently diagnosed cancer among women in the United States, second only to skin cancer. Over 250,000 new invasive breast cancer cases are anticipated annually, with nearly 45,000 fatalities expected. One-third of these cases will metastasize, leading to a harrowing five-year survival rate of about 28 percent for those affected by the aggressive HER-2-positive variant, which is present in approximately 20 percent of breast cancer diagnoses.
Given these alarming statistics, the emergence of a treatment like Enhertu that holds the promise of saving many lives is extraordinarily encouraging.
Enhertu Versus Current Treatment Options
The existing standard of care for HER-2-positive breast cancer is TDM1, an antibody-drug conjugate delivered intravenously. While TDM1 has its merits, it does not measure up to the efficacy of Enhertu. AstraZeneca conducted a head-to-head trial involving 500 participants across 15 countries, comparing the two treatments. The findings revealed that after a year, 65 percent of those on TDM1 experienced disease progression or death, while fewer than 25 percent of Enhertu patients faced similar outcomes. Additionally, the time without tumor growth improved significantly from 7.2 months to 25.1 months, translating to a shift from less than one year to over two years of progression-free survival.
Furthermore, Dr. Jonathan Kline, a leading breast cancer researcher at AstraZeneca, noted that around 80 percent of those treated with Enhertu saw significant tumor reduction, with 16 percent achieving complete disappearance of tumors on imaging scans.
Currently, Enhertu is FDA-approved only for patients with metastatic or inoperable HER-2-positive breast cancer who have not responded to other therapies, including the standard treatment. However, many experts, including Dr. Kline, believe that Enhertu is poised to become the preferred option for most patients with HER-2-positive breast cancer following chemotherapy.
Minimal Side Effects
As with most cancer treatments, side effects are a consideration. Enhertu is no exception, with potential risks that include impacts on the heart, lungs, and white blood cell counts. Fortunately, AstraZeneca reported no significant safety issues or severe lung disease events during the trials. Dr. Rachel Simmons, an oncologist not affiliated with the AstraZeneca study, echoed this sentiment, stating, “The side effects are minimal to none for most patients.”
A cancer diagnosis can evoke a whirlwind of emotions, especially when paired with a dire prognosis. However, hope flourishes with innovative treatments like Enhertu, offering a glimmer of possibility for those affected by HER-2-positive breast cancer. Researchers are also exploring Enhertu’s potential effectiveness for other cancers, such as stomach and lung cancers, hoping to expand its impact.
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In summary, AstraZeneca’s Enhertu presents a groundbreaking treatment for HER-2-positive metastatic breast cancer, significantly improving survival rates and offering hope to patients. As researchers continue to explore its potential for other cancers, the medical community remains optimistic about this innovation.
Keyphrase: AstraZeneca breast cancer drug Enhertu
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