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A groundbreaking new breast cancer medication from AstraZeneca is making waves by significantly lowering the risk of death and tumor progression. The drug, Enhertu, has demonstrated a remarkable 72% reduction in these risks compared to the existing standard treatment, Kadcyla. This significant finding comes from a comprehensive clinical trial.
The DESTINY-Breast03 Trial
The trial, known as DESTINY-Breast03, involved 500 women diagnosed with metastatic breast cancer—an advanced stage where tumors have spread to various parts of the body. The results were striking: 75.8% of patients treated with Enhertu showed no signs of disease progression after one year, whereas only 34.1% of those on Kadcyla achieved the same outcome.
Dave Fredrickson, AstraZeneca’s oncology head, stated, “We’ve never seen such a substantial benefit in metastatic breast cancer before.” Ken Takeshita, global research and development lead at Daiichi Sankyo, highlighted that nearly all patients treated with Enhertu were alive after one year, showing promise for this medication to revolutionize treatment for HER2-positive metastatic breast cancer.
Groundbreaking Results
Susan Galbraith, Executive Vice President for Oncology R&D, described the trial results as “ground-breaking,” noting that Enhertu tripled progression-free survival rates compared to T-DM1, with a disease control rate surpassing 95% against 77% for the previous treatment. She emphasized that these unprecedented results could signal a paradigm shift in managing HER2-positive metastatic breast cancer.
AstraZeneca’s Commitment
AstraZeneca, known for its COVID vaccine developed with Oxford University, acquired Enhertu through a substantial $6.9 billion partnership with Daiichi Sankyo. The company is optimistic about the potential for Enhertu to be utilized in earlier stages of breast cancer treatment, aiming to improve outcomes for patients beyond just advanced cases.
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In summary, Enhertu’s impressive results in reducing death and tumor progression risks highlight its potential to change the treatment landscape for advanced breast cancer, offering new hope for patients facing this challenging diagnosis.
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